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KMID : 0363320190400010070
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Journal of Korean Oriental Internal Medicine
2019 Volume.40 No. 1 p.70 ~ p.88
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Review of Domestic Research on Korean Medicine for Pancreatic Cancer
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Han Ga-Jin
Jeong Ha-Yeong
Park Eun-Joo
Lee A-Reum
Lee Jun-Myung
Seong Shin
Kim Sung-Su
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Abstract
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Objective: This study investigated the trends in pancreatic cancer research on Korean medicine in order to establish a direction for further study.
Methods: Pancreatic cancer research on Korean medicine was reviewed using databases such as OASIS, KoreanTK, KISS, RISS, KISTI, and NDSL. The search terms were “pancreatic cancer” “Korean medicine,” and “herbal medicine.” There was no restriction on publication dates, and the reviewed studies were analyzed according to the type of research.
Results: Nineteen studies were reviewed. The numbers and types of research were as follows: 9 clinical studies including case reports, 2 review studies, and 8 in vitro studies; there was no in vivo study. Among the clinical research were 3 descriptive studies and 6 case reports. The baseline characteristics and quality of life of pancreatic cancer patients were analyzed in the descriptive studies. In the case reports, interventions such as herbal medicine, pharmacopuncture, and acupuncture were used. Research articles on the review of pancreatic cancer were titled “Preliminary Study for Development of Korean Medicine Clinical Practice Guideline for Pancreatic Cancer” and “Systemic Review on the Tumor Dormancy Therapy.” Cell lines such as PANC-1, MIA PaCa-2, and AsPC-1 were used for in vitro studies. These studies have reported decreased cell viability, induced apoptosis, and changes in cancer-related gene expression.
Conclusion: Through this review, we found that using Korean medicine for treating pancreatic cancer is applicable. However, due to overall limited the number of study, the benefit of Korean medicine for pancreatic cancer may be substantiated to a limited degree. Better methodological quality and large controlled trials are expected to further quantify the therapeutic effect of Korean medicine.
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KEYWORD
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pancreatic neoplasm, Korean traditional medicine, review
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